Pair Name	Capsaicin, Docetaxel
Disease Info	[ICD-11: 2C82]	Prostate cancer		Investigative
Gene Regulation	Up-regulation	Phosphorylation	ACACA	hsa31
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	MTOR	hsa2475
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Down-regulation	Phosphorylation	RPS6	hsa6194
	Up-regulation	Phosphorylation	STK11	hsa6794
In Vitro Model	PC-3	Prostate carcinoma	Homo sapiens (Human)	CVCL_0035
	LNCaP	Prostate carcinoma	Homo sapiens (Human)	CVCL_0395
In Vivo Model	Prostate tumors were induced in athymic mice by subcutaneal injection of 5×10⁶ PC-3 cells or 5×10⁶ LNCaP cells, according to the experiment.
Result	We showed that the synergistic anti-proliferative effect may be attributed to two independent effects: Inhibition of the PI3K/Akt/mTOR signaling pathway by one side, and AMPK activation by the other. In vivo experiments confirmed the synergistic effects of docetaxel and capsaicin in reducing the tumor growth of PC3 cells.